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A decade spent on clinical studies

Over eight years of research and product development at Karolinska Institutet (KI) and the Swedish School of Sport and Health (GIH), has resulted in successful stabilisation of isothiocyanates, enabling production of Nomio.

The story behind the remarkable discoveries

The group of scientists behind the research on isothiocyanates (ITC) was originally established at Karolinska Institutet. In 2009, Filip Larsen joined as an M.Sc. student, contributing to Jon and Eddie’s groundbreaking research on Nitrate. Michaela Sundqvist joined the group as a PhD student in 2014. After several years of collaboration, Filip transitioned to the Swedish School of Sport and Health Sciences (GIH), where his research has focused on exercise adaptations and muscle physiology in elite athletes. At GIH, Filip initiated the research on ITC and exercise adaptations, with the first study published in 2023. Michaela joined his research group as a postdoctoral fellow in 2021 and led the most recent study on the acute effects of ITC intake.

Filip Larsen

Docent, Institution of Physiology, Nutrition and Biomechanics Swedish School of Sports and Health Sciences.

Michaela Sundqvist

Post-doc, Institution of Physiology, Nutrition and Biomechanic Swedish School of Sports and Health.

Jon Lundberg

Professor of Pharmacology Karolinska Institute. Originator of Research on Nitric Oxide for exercise.

Eddie Weitzberg

Professor of Pharmacology Karolinska Institute. Originator of Research on Nitric Oxide for exercise.

ITC for Endurance Training

New research explore ITC's (isothiocyanates) relation to endurance efforts by activation of NRF2

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Pioneering research on ITC for endurance sports

In a double-blinded cross-over study, the NRF2-activating properties of ITC was connected to training adaptations - participants who took ITC saw faster training improvements compared to placebo.

Headline saw a shift in blood lactate compared to placebo.

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Published as a pre-print in 2025, investigated the acute effects of ITC. The study saw that a single dose of ITC was correlated to a shifted blood lactate curve during sub-maximal exercise.

It was also found that the optimal ITC dose follows a U-shaped curve, with the optimal amount matching the ITC content in one Nomio shot.

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In an independent study by David Hood of York University, muscle fibers were stimulated with electricity to emulate exercise, while being exposed to ITC.

Hood's experiment linked biogenesis of mitochondria and muscle fibers to electric stimulation in combination with ITC exposure.

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The results from early studies done on ITC has made it the next frontier for research in sports science and nutrition

NRF2-activation when taking ITC

A previously well-researched interaction is the activation of the NRF2-system in the body - a regulator of antioxidative enzymes produced in the body.

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Shifts in lactate and glycogen metabolization after consumption of ITC

The isothiocyanates present in glucosinolate-rich broccoli sprouts were connected to moderated lactate levels and specific exercise intensities

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Impacted muscular atrophy during ITC exposure

In a double-blinded cross-over study, sulforaphane (an isothiocyanate) was linked to protection of muscle fibers in test tube tests

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ITC impact on acute training tests

The study explored how a single dose of ITC previous sub-maximal exercise affects exercise performance and metabolism

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Background

Other research on ITC and broccoli sprouts

Sulforaphane Supplement Eases Muscle Soreness Post-Exercise

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NRF2 Activation Boosts Exercise Endurance via Muscle Redox Modulation

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Sulforaphane Protects Muscles from Exercise-Induced Damage

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Sulforaphane Prevents Age-Related Muscle Decline via NRF2

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Nomio

The world’s best athletes changed their ritual. Follow the record-breaking routine.

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Completely natural ingredients

8 months durability

Easy to transport in room temp

Patent-pending formula

Frequently asked questions

Nomio has a best-before date 8 months after production if stored refrigerated. However, they last up to 8 weeks in room temperature, making it easy to bring it to trainings or travel it.

Nomio's research team consists of many of the scientists who found the benefits of Nitrate in training. With research conducted for over 8 years at Karolinska Institute and Swedish School of Sports Science, there are robust data underlining the effects of Nomio. Read more under "Our Science".

Nomio is best included both in training and racing routines. Our recommendation is to take it 3 hours before hard sessions or races, as a hard effort routine. It can also be taken 1 hour before bed time on especially hard days. Many professional athletes use Nomio 1-4 times per week.

Nomio is shown to be highly beneficial to athletes of almost all levels. There seems to be an even stronger effect than average in elite athletes, and a less strong effect in those who rarely or never work out. Nomio's research is conducted on a mixed set of participants, ranging from sub-elite to recreational endurance athletes.

We're commited to clean sports. Nomio is regularly tested for select banned substances.
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